U 18666A

Описание:

U18666A, a cationic amphiphile/sterol, has a diethylaminoethyl chain linked to the 3-hydroxyl. It is an androstenolone derivative.

Применение:

U 18666A has been used in fibroblast controls to study the mechanism of increase in autophagy in Niemann-Pick Disease Type C (NPC) cells. U 18666A has been used:as a competitive inhibitor of the Niemann-Pick disease, type C (NPC2) binding partner Niemann-Pick C1 (NPC1) to treat symbiotic and aposymbiotic adult Aiptasia to study the effect of global sterol transport inhibitionin treating seminiferous tubules to study its effects on the localization pattern of VPS35-positive vesiclesto study the U18666A treatment effects on early endosomes and late endosomes/multivesicular bodies (MVBs)as an NPC1 inhibitor to test its in vivo efficacy and study its effects on filovirus entry and infection